NASP modulates histone turnover to drive PARP inhibitor resistance

Nature
11m read

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09414-z

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.
www.nature.com