Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10409-7

Insights into the structural basis of fungal β-1,3-d-glucan synthase inhibition by caspofungin lay the groundwork for the development of next-generation echinocandins with increased potency, broader antifungal spectrum, and reduced propensity for resistance.