Dynamics of genetic and somatic trade-offs in ageing and mortality

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10407-9

Mapping DNA variants that modulate mortality using a starting population of 6,438 young mice defined 29 distinct loci that influence lifespan and mortality with divergent age- and sex-specific effects, as well as 30 loci that specifically couple body mass with longevity.