Israel-Iran conflict live: major explosion reported in Tehran as Israel says it targeted ‘centrifuge production’ site

US president Trump calls for Iran’s ‘unconditional surrender’, issuing a veiled threat to kill its supreme leader as conflict enters fifth day

• Analysis: Israel’s gamble on force could push Iran to accelerate nuclear plans

In the span of a few days, Israel has killed more than a dozen of Iran’s top nuclear scientists, taken out much of its military hierarchy, and launched a wave of attacks against its nuclear programme, writes the Guardian’s chief Middle East correspondent, Emma Graham-Harrison, in this compelling analysis.

“It has been a powerful display of Israeli military and intelligence dominance, but has not critically damaged Iran’s widely dispersed and heavily protected nuclear programme, Israeli military commanders and international nuclear proliferation experts agree.”