Parent-of-origin effects found for gene variants that affect human growth and metabolism

Nature, Published online: 06 August 2025; doi:10.1038/d41586-025-02391-3

A genome-wide analysis has identified genetic variants that have different effects on human growth and metabolic traits depending on their parental origin. Often, the same variant will push traits in opposite directions depending on its parental origin, in line with a hypothesized conflict between the ‘interests’ of the two parents’ genomes.