WEE1 opposes APC/C^CDH1 activity to promote S phase entry

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x

Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.