Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

Nature, Published online: 22 April 2026; doi:10.1038/s41586-026-10343-8

CASP5 expression is restricted to the human intestinal epithelium, and the CASP5C isoform has a key role in promoting Wnt signalling, which is required for epithelial homeostasis, through binding to dishevelled and cleavage of APC to regulate β-catenin turnover.