Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi worked on how the immune system can be prevented from harming the body

The Nobel prize in physiology or medicine 2025 has been awarded to three scientists for their work on how the immune system is kept in check and prevented from attacking our own body.

Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the prize “for their discoveries concerning peripheral immune tolerance”.