BURSTNature, Published online: 21 May 2025; doi:10.1038/s41586-025-09017-8
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.