DICER cleavage fidelity is governed by 5′-end binding pockets

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10211-5

Cryo-electron microscopy and massively parallel assays shed light on the mechanism by which DICER, a key enzyme in the RNase III family, cleaves RNA at precise locations to produce small RNAs.