Solid phase transitions as a solution to the genome folding paradox

Nature
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Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-09043-6

In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.
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