Expanding the cytokine receptor alphabet reprograms T cells into diverse states

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09393-1

Orthogonal chimeric receptors containing intracellular domains for IL-4R, IL-20R, IL-22R and GCSFR reprogram T cells to promote distinct natural and synthetic cell states with functional and therapeutic implications.